Zaditor (ketotifen fumarate) Antihistamine Eye Drops

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  Novartis Pharma US

 

FOR HEALTHCARE PROFESSIONALS


ORIGINAL PRESCRIPTION STRENGTH ZADITOR IS AVAILABLE OTC!

(ketotifen fumarate ophthalmic solution)

LONG-LASTING EFFECTIVENESS COMES TO OTC OCULAR ITCH RELIEF

The FIRST OTC that provides triple modes of action for ocular itch relief

Potent antihistamine effect1
Potent H1 receptor antagonist to prevent acute
histamine-mediated allergy symptoms.
Mast cell stabilization2
Inhibits mast cell degranulation to prevent the
release of inflammatory mediators including histamine.
Eosinophil inhibition3
Prevents the release of mediators of the late phase
allergic reaction.

The FIRST OTC antihistamine eye drop that lasts up to 12 hours per dose4*




Single-center, double-masked, controlled clinical trial in CAC**model.
Allergen challenges were conducted at 5 minutes and 12 hours after treatment.

Plus fast relief — starts to work in minutes4*




Post-allergen challenge, Zaditor provided rapid ocular itch relief — in minutes.


ZADITOR Lasts up to 12 hours with single dose4
Offers patients freedom from frequent dosing with all-day relief
Pediatric dosing advantage for young and school-age children

ZADITOR Is safe and effective for children as young as 3

ZADITOR Contains no vasoconstrictor
Eliminates concerns for vasoconstrictor overuse

AND, ZADITOR Relieves itching FAST — starts to work in minutes4


*Adapted from Greiner **Conjunctival allergen challenge
1. Sharif NA, Xu SX, Yanni JM. Olopatadine (AL-4943A):ligand binding and functional studies on a novel, long acting H1 selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. J Ocul Pharmacol Ther. 1996;12(4):401-407.
2. Schoch C. In vitro inhibition of human conjunctival mast-cell degranulation by ketotifen. J Ocul Pharmacol Ther. 2003; 19(1):75-81.
3. Woerly G. Loiseau S, Loyens M, et al. Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils:consequences for allergic eye diseases. Allergy. 2003; 58(5):397-406.
4. Greiner JV, Minno G. A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model. Clin Ther. 2003; 25(7):1988-2005.

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