Zaditor (ketotifen fumarate) Antihistamine Eye Drops

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  Novartis Pharma US

 

FOR HEALTHCARE PROFESSIONALS


ORIGINAL PRESCRIPTION STRENGTH ZADITOR IS AVAILABLE OTC!

(ketotifen fumarate ophthalmic solution)

LONG-LASTING EFFECTIVENESS COMES TO OTC OCULAR ITCH RELIEF

The FIRST OTC eye drop that provides triple modes of action for ocular itch relief.

Potent antihistamine effect1
Potent H1 receptor antagonist to prevent acute
histamine-mediated allergy symptoms.
Mast cell stabilization2
Inhibits mast cell degranulation to prevent the
release of inflammatory mediators including histamine.
Eosinophil inhibition3
Prevents the release of mediators of the late phase
allergic reaction.

The FIRST OTC antihistamine eye drop that lasts up to 12 hours per dose4*




Single-center, double-masked, controlled clinical trial in CAC**model.
Allergen challenges were conducted at 12 hours after treatment of 0.025% Zaditor or placebo

Plus fast relief — starts to work in minutes4*




Post-allergen challenge, Zaditor provided rapid ocular itch relief — in minutes.


First OTC eye drop that provides triple modes of action Fights ocular itch for up to 12 hours with a single drop
Offers patients freedom from frequent dosing with all-day relief
Pediatric dosing advantage for young and school-age children
Relieves itching FAST-starts to work in minutes4

Safe and effective for children aged 3 years and older

Contains no vasoconstrictor
Eliminates concerns for vasoconstrictor overuse
Full prescription strength with an OTC price


*Adapted from Greiner **Conjunctival allergen challenge
1. Sharif NA, Xu SX, Yanni JM. Olopatadine (AL-4943A):ligand binding and functional studies on a novel, long acting H1 selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. J Ocul Pharmacol Ther. 1996;12(4):401-407.
2. Schoch C. In vitro inhibition of human conjunctival mast-cell degranulation by ketotifen. J Ocul Pharmacol Ther. 2003; 19(1):75-81.
3. Woerly G. Loiseau S, Loyens M, et al. Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils:consequences for allergic eye diseases. Allergy. 2003; 58(5):397-406.
4. Greiner JV, Minno G. A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model. Clin Ther. 2003; 25(7):1988-2005.

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